U-Penn Research Team Makes New Strides with TBIs

iStock_000011091853_LargeAs Brain Injury Awareness Month continues here in Virginia, we’re very pleased to report a new step in understanding concussions that comes from an interdisciplinary team of researchers at the University of Pennsylvania.

Recognizing that even so-called “mild” forms of traumatic brain injury can result in lifelong damage, the team is using mathematical modeling to understand exactly how the brain becomes concussed. The team includes a professor of material science and engineering, a professor of neurosurgery and a laboratory technician. They have joined forces to figure out how to protect the brain from the effects of traumatic injury.

Flexible…Yet Fragile?

It’s long been known that brain cells have long, tendril-like parts called axons, which are notoriously elastic. The mystery is why these stretchy, flexible axons would break so easily under brain trauma.

The answer appears to lie with the protein that holds the axons together. The protein is called tau, and it binds together the tiny microtubules that make up an axon. While tau is very flexible, the microtubules are not. And those microtubules are what transport molecular cargo throughout the brain.

Dr. Douglas Smith, one of the members of the research team and director of the Penn Center for Brain Injury and Repair, explains it like this:

“One of the main things you see in the brains of patients who have died because of a TBI is swellings along the axons. When [the microtubules] break, there’s an interruption in the flow of this cargo and it starts to accumulate, which is why you get these swellings.”

The Protein Mystery

The next question the team had to answer was why the microtubules break. After all, the stretchy protein tau ought to work like a bungee cord, keeping the microtubules safe even when trauma occurs.

But what they found was that tau is viscoelastic. Put another way, the protein acts a lot like Silly Putty.

“When you add stress to it slowly, it stretches a lot,” said Vivik Shenoy, the engineering expert on the team, in a Phys.org article. “But if you add stress to it rapidly, like in an impact, it breaks. If you’re in a situation where the tau doesn’t stretch, such as what happens in fast strain rates, then all the strain will transfer to the microtubules and cause them to break.”

Nearly any brain trauma essentially causes the brain cells to stretch to accommodate the impact. What these findings indicate is that the speed of that stretch could be the most important determining factor in the severity of a traumatic brain injury.

Promising Steps Forward

The findings from this study will be used, in the short-term, to improve working models of the brain for better diagnoses of injury and to help with designing preventive measures.

Farther down the line, it may even be possible to design drugs that make microtubules less breakable and axons more flexible so that accidental injuries can be lessened.

Long-term, the hope is to help with diseases like Alzheimer’s and chronic traumatic encephalopathy, which are related to degeneration of the tau protein.

For now, it’s exciting just to see traumatic brain injury being addressed by serious, motivated scientists like these.

 Need Help?

If you or a loved one have suffered traumatic brain injury and don’t know where to turn, get the help you need from Brain Injury Law Center. We are here to help you seek the compensation you deserve, so that you can have every available resource to help. Call us at (757) 244-7000 for a no-cost, no-obligation consultation, or fill out the form on the left side of this page.

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